Publications

Books and Reviews

Harrington, P.J.  “Pharmaceutical Process Chemistry for Synthesis: Rethinking the Routes to Scale-Up”, John Wiley & Sons, Inc., Hoboken, 2011.

Abrecht, S.; Harrington, P.; Iding, H.; Karpf, M.; Trussardi, R.; Wirz, B.; Zutter, U.  “The Synthetic Development of the Anti-Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu®): A Challenge for Synthesis & Process Research”, Chimia  2004, 58, 621 [Chem. Abstr. 142:336053].

Harrington, P.J.; Lodewijk, E.L. “Twenty Years of Naproxen Technology”, Org. Proc. Res. Dev. 1997, 1, 72 [Chem. Abstr. 126:61806].
One of the top-ten most cited articles in Organic Process Research & Development, Vols. 1-10.

Harrington, P.J. ”Transition Metal Allyl Complexes: Trimethylenemethane Complexes”, Comprehensive Organometallic Chemistry II, Volume 12, Elsevier Science, Ltd., Oxford, UK, 1995.

Harrington, P.J.  “Transition Metal Allyl Complexes: Pd, W, Mo-Assisted Nucleophilic Attack”, Comprehensive Organometallic Chemistry II, Volume 12, Elsevier Science, Ltd., Oxford, UK, 1995.

Harrington, P.J.  “Transition Metals in Total Synthesis”, John Wiley & Sons, Inc., New York, 1990 [Chem. Abstr. 113:6587].

Research Publications

Harrington, P.J. “Atorvastatin Calcium: Structural Complexity to Synthetic Simplicity with Help from Nature”, Process Development and Scale-Up in the Pharmaceutical Industry Master Class at NUI Galway, Galway, Republic of Ireland, April 2012.

Harrington, P.J. “Bosentan: Is Process Improvement Possible after the Yield has been Optimized?”, Process Development and Scale-Up in the Pharmaceutical Industry Master Class at NUI Galway, Galway, Republic of Ireland, April 2012.

Harrington, P.J.  Streamlining Proess R & D: “Lessons Learned from Escitalopram”, 5th International Current Process Chemistry Conference, 02 June 2011, Philadelphia, PA.

Harrington, P.J.; Hildbrand, S.; Sarma, K.  “Process for the Preparation of 4’-Azido Cytidine Derivatives”, US7632940 (12/15/2009).

Harrington, P.J.; Paulsen V.G.; Tucker, C.E.  “Process for Preparing Pyrazole Functionalized Benzodiazepinones”, WO2009100996 (8/20/2009).

Harrington, P.J.; Paulsen V.G.; Tucker, C.E.  “Process for Preparing Pyrazole Functionalized Benzodiazepinones”, US20090203901 (8/13/2009).

Brown, J.D.; Dauer, R.; Harrington, P.J.; Johnston, D.A.; Khatri, H.N.; Rowe, G.K.; Topping, R.J.  “Process for S-Aryl Cysteine”, EP1236715 (10/15/2008). 

Harrington, P.J.; Hildbrand, S.; Sarma, K.  “Process for Preparation of 4’-Azido Cytidine Derivatives”, WO2008071571 (6/19/2008).

Harrington, P.J.; Johnston, D.A.; Hodges, L.M.  “Process for Preparation of Pyridine Derivatives of NK-1 Receptor Antagonist”, US7384939 (6/10/2008).

Harrington, P.J. “Compounds and Methods for Carbazole Synthesis”, WO2007077111 (7/12/2007) [Chem. Abstr. 147:166194].

Harrington, P. J; Khatri, H.N.  “Preparation of Cyclic, Ketalized Ketones by Favorskii Rearrangement and the Use Thereof for the Preparation of Glucokinase Activator 70”, WO2007048717 (5/3/2007) [Chem. Abstr. 146:482076].

Harrington, P.J.; Johnston, D.; Moorlag, H.; Wong, J-W.; Hodges, L.M.; Harris, L.; McEwen, G.K.; Smallwood, B.  “Research and Development of an Efficient Process for the Construction of the 2,4,5-Substituted Pyridines of NK-1 Receptor Antagonists”, Org. Proc. Res. Dev. 2006, 10, 1157[Chem. Abstr. 146:83545].

Harrington, P.J.; Hodges, L.M.; Johnston, D.A. “Process for Preparing Pyridinecarboxamide Derivatives used as Intermediates in the Synthesis of NK-1 Receptor Antagonists”, WO2006002860 (1/12/06) [Chem. Abstr. 144:128858].

Harrington, Peter J. “Construction of the Pyridine Core of NK-1 Receptor Antagonists”,
Gordon Research Conference on Organic Reactions and Processes, 2 August, 2005, 
Bryant University, Smithfield, RI.

Goehring, W.; Harrington, P.J.; Hodges, L.M.; Johnston, D.A.; Rimmler, G. “Process for Preparation of 4-Phenylpyridine-3-carboxamide Derivatives”, US2005014792 (1/20/05) [Chem. Abstr. 142:134474].

Brown, J.D.; Harrington, P.J.; Hughes, R.C.  “Process for Preparing 1,2-Diamino Compounds”, US7122684 (10/17/06) [Chem. Abstr. 141:277243].

Brown, J.D.; Khatri, H.N.; Harrington, P.J.; Johnston, D.A.; Topping, R.J.; Dauer, R.R.; Rowe, G.K. “Preparation for S-Aryl-Cysteine and Its Derivatives”, US6765109 (7/20/04).

Harrington, Peter J. “Construction of the Pyridine Core of NK-1 Receptor Antagonists”, 10th International Conference on Organic Process Research & Development, 15 July, 2004, Vancouver, BC.

Harrington, P.J.; Brown, J.D.; Foderaro, T.; Hughes, R.C.  “Research and Development of a Second-Generation Process for Oseltamivir Phosphate, Prodrug for a Neuraminidase Inhibitor”, Org. Proc. Res. Dev. 2004, 8, 86 [Chem. Abstr. 140:148071].
One of the most-accessed articles (#15) in Organic Process Research & Development, Vol. 8. 

Harrington, Peter J.  “Synthetic Strategy in Process Evaluation and Optimization,” 7th International Conference on Organic Process Research & Development, 17 March 2003, New Orleans, LA.

Harrington, P.J.; Khatri, H.N.; DeHoff, B.S.; Guinn, M.R.; Boehler, M.A.; Glaser, K.A.
“Research and Development of a Second Generation Process for Bosentan, an Endothelin Receptor Antagonist”, Org. Proc. Res. Dev. 2002, 6, 120 [Chem. Abstr. 136:279420].

Harrington, P.J.; Khatri, H.N.; Schloemer, G.C. “Preparation of Ketorolac”, US6323344 (11/27/01) [Chem. Abstr. 134:207709].

Harrington, P.J.; Hodges, L.M.; Puentener, K.; Scalone, M. “Synthesis of 3,6-Dialkyl-5,6-dihydro-4-hydroxy-pyran-2-one”, US6552204 (4/22/03) [Chem. Abstr. 135:166783].

Brown, J.D.; Khatri, H.N.; Harrington, P.J.; Johnston, D.A.; Topping, R.J.; Dauer, R.R.; Rowe, G.K. “Preparation for S-Aryl-Cysteine and Its Derivatives”, US6229041 (5/8/01) [Chem. Abstr. 132:64525].

Harrington, P.J.; Khatri, H.N.; Schloemer, G.C. “Preparation of Ketorolac”, US6197976 (3/6/01) [Chem. Abstr. 134:207709].

Harrington, P.J.; Khatri, H.N.; DeHoff, B.S. “Preparation of Sulfonamides”, US6136971 (7/15/99) [Chem. Abstr. 133:309904].

Harrington, P.J. “Preparation of Mibefradil via an Acetamide Anion”, US5892055 (4/6/99).

Wong, J-w.; Harrington, P.J. “Preparation of Mibefradil via an Acetonitrile Anion”, US5811557 (9/22/98) [Chem. Abstr. 129:245150].

Harrington, P.J.; Wong, J-w. “Preparation of Mibefradil via a Naphthalenylacetic Acid”, US5811556 (9/22/98) [Chem. Abstr. 129:245149].

Harrington, P.J.; Fleming, M.P. “Preparation of Mibefradil via an Acetamide Anion”, US5808088 (9/15/98) [Chem. Abstr. 129:230726].

Harrington, P.J.  “Second Generation Process Design and Development for Posicor: How to Convert Simple Chemical Knowledge to Millions in Profit”, CU-Roche Colorado Synthetic Chemistry Symposium, 21 May 1998, Boulder, CO
.
Harrington, P.J.; Lodewijk, E.L. “Twenty Years of Naproxen Technology”, 13th SCI Process Development Symposium, 13 December 1995, Stevenage, Herts, UK.

Harrington, P.J.  J. Amer. Chem. Soc. 1995, 117, 1861 (book review) [Chem. Abstr. 1995:352158].

Schloemer, G.C.; Han, Y-K.; Harrington, P.J. “Preparation of Acyclovir Using 1,3-Dioxolane”, US5567816 (10/22/96) [Chem. Abstr. 126:19174].

Harrington, P.J., Sanchez, I.H.  “N-p-Toluenesulfonylpyrroles from 1,3-Dienes”, Syn. Comm. 1994, 24, 175 [Chem. Abstr. 120:191464].

Harrington, P.J.; Sanchez, I.H.  “Application of the Cyanurate-Isocyanurate Rearrangement to Amine Synthesis: Preparation of 2-(2-Thienyl)ethylamine”, Syn. Comm. 1993, 23, 1307 [Chem. Abstr. 119:160016].

Harrington, P.J.; Sanchez, I.H.  “Preparation of 2-(2-Thienyl)ethylamine and Thieno[3,2-c]-pyridine Derivatives”, EP522956 (1/13/93) [Chem. Abstr. 118:254911].

Beardsley, G.P.; Fletcher, S.R.; Harrington, P.J.; Taylor, E.C.  “Pyrido[2,3-d]pyrimidine Derivatives -Intermediates in Forming Anti-neoplastic Agents”, US5026852 (6/25/91).

Hegedus, L.S.; Sestrick, M.R.; Michaelson, E.T.; Harrington, P.J.  “Palladium Catalyzed Reactions in the Synthesis of 3- and 4-Substituted Indoles.4.”, J. Org. Chem. 1989, 54, 4141 [Chem. Abstr. 111:115652].

Beardsley, G.P.; Fletcher. S.R.; Harrington, P.J.; Taylor, E.C.  “New Glutamic Acid Compounds Useful as Antineoplastic Agents - N-(4-((2-Amino-4-substituted-pyrido[2,3- d]pyrimidinyl)alkyl)-benzoyl-L-glutamic Acid Derivatives”, US4845216 (7/4/89).

Hegedus, L.S.; Toro, J.L.; Miles, W.H.; Harrington, P.J.  “Palladium-Catalyzed Reactions in the Synthesis of 3- and 4-Substituted Indoles. III. Total Synthesis of (+)-Aurantioclavine”, J. Org. Chem. 1987, 52, 3391 [Chem. Abstr. 107:134536].

Harrington, P.J.; DiFiore, K.A.  “A Preparation of 3-Aryl-2,5-dihydrothiophene-1,1-dioxides from Aryl Iodides”, Tetrahedron Lett. 1987, 28, 495 [Chem. Abstr. 107:134147].

Harrington, P.J.; Hegedus, L.S.; McDaniel, K.F.  “Palladium-Catalyzed Reactions in the Synthesis of 3-and 4-Substituted Indoles. II. Total Synthesis of the N-Acetyl Methyl Ester of (+)-Clavicipitic Acids”, J. Amer. Chem. Soc. 1987, 109, 4335 [Chem. Abstr. 107:78139].

Taylor, E.C.; Wong, G.S.K.; Fletcher, S.R.; Harrington, P.J.; Beardsley, G.P.; Shih, C.J.  “Chem. Biol. Pteridines, 1986, Pteridines Folic Acid Deriv., Proc. Int. Symp. Pteridines Folic Acid Deriv.: Chem., Biol. Clinical Aspects, 8th, 1986 [Chem. Abstr. 107:176424].

Taylor, E.C.; Harrington, P.J.; Fletcher, S.R.; Beardsley, G.P.; Moran, R.G.  “Synthesis and Anti-leukemic Activity of 5,10-Dideazaaminopterin and 5,10-Dideaza-5,6,7,8-tetrahydroaminopterin”,  J. Med. Chem. 1985, 28, 914 [Chem. Abstr. 103:6676].

Hegedus, L.S.; Harrington, P.J.  “Palladium Catalysis in the Synthesis of Nitrogen Heterocycles”, ACS Meeting, Great Lakes and Central Regions, Kalamazoo, MI, 1984.

Harrington, P.J.; Hegedus, L.S.  “Palladium-Catalyzed Reactions in the Synthesis of  3- and 4-Substituted Indoles - Approaches to the Ergot Alkaloids”, J. Org. Chem. 1984, 49, 2657 [Chem. Abstr. 101:54853].

Hegedus, L.S.; Harrington, P.J.  “Organopalladium Routes to the 4-Substituted Indoles and Clavines”, 18th Annual ACS Midwest Regional Meeting, Lawrence, KS, 1983.

Beardsley, G.P.; Fletcher, S.R.; Harrington, P.J.; Taylor, E.C.  “New Tetrahydropyrido[2,3-d]pyrimidines - Useful as Antineoplastic Agents, in the Manner of  Methotrexate”, US4684653 (8/4/87).

Taylor, E.C.; Beardsley, G.P.; Harrington, P.J.; Fletcher, S.R. “N-[(Pyridopyrimidinylethyl)benzoyl]glutamic Acid Derivatives”, PCT Int. Appl. WO 86005181 (9/12/86) [Chem. Abstr. 106:33470].

Taylor, E.C.; Palmer, D.C.; George, T.G.; Fletcher, S.R.; Tseng, C.P.; Harrington, P.J.; Beardsley, G.P.  “Biological Activity of L-5-Deazafolic Acid and L-5-Deazaaminopterin: Synthetic Strategies to 5-Deazapteridines”, J. Org. Chem. 1983, 48, 4852 [Chem. Abstr. 101:55505 and 100:103829].

Taylor, E.C.; Tseng, C.P.; Harrington, P.J.; Beardsley, G.P.; Rosowsky, A.; Wick, M.  “Chem. Biol. Pteridines, Proc. Int. Symp. Pteridines Folic Acid Deriv.: Chem. Biol. Clin. Aspects, 7th, 1982 [Chem. Abstr. 100:68665].

Harrington, Peter John  “Synthetic Approaches to 5-Deaza- and 5,10-Dideazafolic Acid Analogs”, Diss. Abstr. Int. B  1982, 43, 138 [Chem. Abstr. 98:179838].

Taylor, E.C.; Palmer, D.C.; Fletcher, S.R.; Harrington, P.J.  “Deazaantifolates”, 8th International Congress of Heterocyclic Chemistry, Karl-Franzens Universitat, Graz, Austria, 1981.